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Scientists May Have Found Mechanism Behind Cognitive Decline in Aging in Mice
news.cuanschutz.edu/news-stori
Discussion: news.ycombinator.com/item?id=3

* misregulation of brain protein CaMKII (crucial for memory, learning)
* suggests pharmacological treatment strategies

Paper [mouse model]:
Decreased nitrosylation of CaMKII causes aging-associated impairments in memory & synaptic plasticity in mice
science.org/doi/10.1126/scisig

CaMKII: en.wikipedia.org/wiki/Ca2%2B/c

#neuroscience #cognition #ageing #CognitiveDecline

@GottaLaff I suggest his American citizenship be stripped and he be deported, along with his failing, right wing social media platform. He can afford to live anywhere. Make him make that choice.

I think a lot about how the #evangelicals that I grew up around turned into #Christofascists.

The pentecostals talked constantly about the afterlife. Heaven. In but not of the world. How did they get from that (which came with its own problems such as climate denial) to wanting to dominate and rule every aspect of society?

#Dominionism is the theological justification, but I think it's a subconscious realization that they wasted their time. They want their reward and power now.

They're not taking chances on the afterlife.

#exvangelical #musings

Trump's political action committee that has been paying Trump’s legal fees requested a refund on a $60 million contribution it made to the super PAC supporting the Republican front-runner

The decision of Trump’s political team to ask for a refund of money that was meant to help his 2024 campaign, and was instead diverted to an account paying his legal bills, is extraordinary. It reflects the choice to spend donor cash on lawyers rather than on television advertising

dnyuz.com/2023/07/29/60-millio

The main PAC funding Trump’s 2024 campaign spends the bulk of its money on legal fees, not only for Trump, also for many of his employees past and present. The entire operation is so shady. It works a lot like organized crime does, with people getting their legal bills paid to ensure loyalty to the top guy. Details reported here (gift access): wapo.st/452PZXO

Pay attention to your local school boards.

“Why are national groups and right-wing billionaires so involved in the transformation of the Woodland Park School District? Because the Woodland Park School District is where the opportunity to transform all public education first presented itself. And now that they have found a foothold in the Woodland Park district, they’re proclaiming it to be a model for the nation.
Their plans do not end in Woodland Park — the Bradley and Scaife Foundations are not known for limiting the scale of their ambitions — but they started there, and they started there because the conditions were right. “.
#defendpubliceducation #voteblue

supportwpschools.com/2023/07/d

Montana judge temporarily lifts Republican ban on drag performances ahead of major Pride event

The ruling will allow Montana Pride to advertise and hold some of its events in public places.
#News #GOP #Politics #USA #Trump #MAGA #Republicans

politico.com/news/2023/07/29/m

I have frequently heard Christians argue that Christianity is true because atheism “lacks the moral language to explain why [x] is wrong.”

While that statement is simply false on multiple levels, I can’t help but notice that the Christian majority in Florida cannot seem to handle one of the simplest possible moral questions: “Is slavery a bad thing?”

Same methods 'used on the plantation': Black task force member scorches Florida slavery guidelines
rawstory.com/same-methods-used

NPR: Arkansas is temporarily blocked from enforcing a law that would have allowed criminal charges against librarians and booksellers for providing "harmful" materials to minors.#news #NPR npr.org/2023/07/30/1190966505/

We are all atheists about most of the #Gods that man has ever believed in. Some of us just go one #God further. - R. Dawkins

#atheism
Tooted by a #bot!
SN# 3142

Good morning and Happy Sunday to everyone who agrees that Donald trump has nobody to blame but himself for his mounting legal woes.

Nobody forced him to:
- rape E. Jean Carroll
- take, keep, and share the classified documents he took
- try to cover up what he did
- attempt to defraud voters by asking Georgia officials to "find" 11,780 votes
- incite insurrection at the Capitol
- refuse a peaceful transfer of power

He did ALL of that stuff without the help of "the deep state"

He did all of that stuff despite knowing it was illegal, because he's never been held accountable

He's a criminal, and his crooked ass is going to go to prison for the rest of his miserable life

"Neighbors called the police because the boy was asking if he could do yard work to earn money for a new Playstation, the City of Hapeville Police said.... Officer Colleran and some of his friends came together to get the video game system and even a gift card to pay for the membership so the boy could play immediately. " #OrphanCrushingMachine komonews.com/news/nation-world

Trump's political group, Save America, has reportedly spent over $40 million on legal costs this year, raising eyebrows among prosecutors. The PAC, primarily funded by small-dollar contributions, is covering legal expenses for anyone entangled in investigations related to Trump.

washingtonpost.com/national-se

I appreciate the friends I've made during my transition.

I'm having a conversation with one about how I never really got to play with girls' toys as a kid. And deep down, I always wanted a Barbie. And she didn't even bat an eye. She just goes "yeah that makes perfect sense. I played with Barbie and Polly Pocket and all that stuff as a kid. It was fun. We should get you some."

And now we're swapping screencaps back and forth of the ones we each want.

I'm pretty sure we're gonna have a playdate now.

I thought being trans and being honest with others about who I am would be terrifying. But I guess it doesn't have to be.

@AlliFlowers Gosar's WHOLE family hates him & wants him voted out. I can't blame them

Well will ya lookie here at what they did in a small town? They closed the ob/gyn unit at the Henry Co. TN Medical Center.

The Governor offers no solution. Because Republicans don't know how to solve problems, after all, their core belief is that government SHOULDN'T solve problems. That's for the "free hand of the market."

Welp, that free hand just gave women in Henry County the finger.

newschannel5.com/news/newschan

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